Usually, the organization of living systems is explained by appealing to an intrinsic purpose that is based on the biological survival. However, paradigmatically, it is inevitable to observe that the final destiny of all living organisms is death. In this work, we defend that, from an organizational approach, there is a form of death—Regulatory Cell Death—that, far from being a mere "absence of life", is a process of biological regulation and a feature of self-maintenance in multicellular organisms.

The organizational account of biological functions interprets functions as contributions of a trait to the maintenance of the organization that, in turn, maintains the trait. As has been recently argued, however, the account seems unable to provide a unified grounding for both intra- and cross-generation functions, since the latter do not contribute to the maintenance of the same organization which produces them. To face this ‘ontological problem’, a splitting account has been proposed, according to which the two kinds of functions (...) require distinct organizational definitions. In this article, we propose a solution for the ontological problem, by arguing that intra- and cross-generation functions can be said to contribute in the same way to the maintenance of the biological organization, characterized in terms of organizational self-maintenance. As a consequence, we suggest maintaining a unified organizational account of biological functions. (shrink)

We reply to Artiga and Martinez’s claim according to which the organizational account of cross-generation functions implies a backward looking interpretation of etiology, just as standard etiological theories of function do. We argue that Artiga and Martinez’s claim stems from a fundamental misunderstanding about the notion of “closure”, on which the organizational account relies. In particular, they incorrectly assume that the system, which is relevant for ascribing cross-generation organizational function, is the lineage. In contrast, we recall that organizational closure refers (...) to a relational description of a network of mutual dependencies, abstracted from time, in which production relations are irrelevant. From an organizational perspective, ascribing a function to an entity means locating it in the abstract system that realizes closure. In particular, the position of each entity within the relational system conveys an etiological explanation of its existence, because of its dependence on the effects exerted by other entities subject to closure. Because of the abstract relational nature of closure, we maintain that the organizational account of functions does not endorse a backward looking interpretation of etiology. As a consequence, it does not fall prey of epiphenomenalism. (shrink)

In contrast to the “normativist” view, “naturalist” theorists claim that the concept of health refers to natural or normal states and propose different characterizations of healthy and diseased conditions that are meant to be objectivist and biologically grounded. In this article, we examine the core concept of these naturalist accounts of disease, i.e., the concept of biological malfunction, and develop a new formulation of the notion of malfunction following the recent organizational approach to functions in the philosophy of biology. We (...) focus on the notions of adaptive regulation and functional presupposition to develop a new conceptual framework that justifies the ascription of malfunctional behaviors to biological systems according to the embodied normativity of biological organizations. (shrink)

In this paper, we develop an organizational account that defines biological functions as causal relations subject to closure in living systems, interpreted as the most typical example of organizationally closed and differentiated self-maintaining systems. We argue that this account adequately grounds the teleological and normative dimensions of functions in the current organization of a system, insofar as it provides an explanation for the existence of the function bearer and, at the same time, identifies in a non-arbitrary way the norms that (...) functions are supposed to obey. Accordingly, we suggest that the organizational account combines the etiological and dispositional perspectives in an integrated theoretical framework. IntroductionDispositional ApproachesEtiological TheoriesBiological Self-maintenance Closure, teleology, and normativityOrganizational differentiationFunctions C1: Contributing to the maintenance of the organization C2: Producing the functional trait Implications and Objections Functional versus useful Dysfunctions, side effects, and accidental contributionsProper functions and selected effectsReproductionRelation with other ‘unitarian’ approachesConclusions. (shrink)

In the philosophical debate on aging, it is common to raise the question of the theoretical definition of aging in terms of its possible characterization as a disease. Understanding aging as a disease seems to imply its medicalization, which has important practical consequences. In this paper, we analyze the question of whether aging is a disease by appealing to the concept of disease in the philosophy of medicine. As a result of this analysis, we argue that a pragmatist approach to (...) the conception of disease is the best alternative to highlight the relevance of the medicalization of aging. From this pragmatist perspective, it can be seen that the notion of aging is going through a conceptual change, and aging can today be understood as a not radically different process from any other condition that is usually considered a disease. (shrink)

Most of current theoretical analyses on biological functions can be classified as etiological or dispositional, depending on how they deal with the teleological dimension. In this paper, we propose a critical survey of these two perspectives, and we argue that some recent studies have set the basis of a new approach which grounds the teleological dimension of functional attributions in the organizational properties of living systems. We outline a new proposal within this new approach, based on an interpretation of living (...) systems as organized self-maintaining systems. (shrink)

The definitions and conceptualizations of health, and the management of healthcare have been challenged by the current global scenarios (e.g., new diseases, new geographical distribution of diseases, effects of climate change on health, etc.) and by the ongoing scholarship in humanities and science. In this paper we question the mainstream definition of health adopted by the WHO—‘a state of complete physical, mental and social well-being and not merely the absence of disease or infirmity’ (WHO in Preamble to the constitution of (...) the World Health Organization as adopted by the international health conference, The World Health Organization, 1948)—and its role in providing tools to understand what health is in the contemporary context. More specifically, we argue that this context requires to take into account the role of the environment both in medical theory and in the healthcare practice. To do so, we analyse WHO documents dated 1984 and 1986 which define health as ‘coping with the environment’. We develop the idea of ‘coping with the environment’, by focusing on two cardinal concepts: adaptation in public health and adaptivity in philosophy of biology. We argue that the notions of adaptation and adaptivity can be of major benefit for the characterization of health, and have practical implications. We explore some of these implications by discussing two recent case studies of adaptivity in public health, which can be valuable to further develop adaptive strategies in the current pandemic scenario: community-centred care and microbiologically healthier buildings. (shrink)

Our goal in this paper is to articulate a precise concept of at least a certain kind of disease-mongering, showing how pharmaceutical marketing can commercially exploit certain diseases when their best definition is given through the success of a treatment in a clinical trial. We distinguish two types of disease-mongering according to the way they exploit the definition of the trial population for marketing purposes. We argue that behind these two forms of disease-mongering there are two well-known problems in the (...) statistical methodology of clinical trials (the reference class problem and the distinction between statistical and clinical significance). Overcoming them is far from simple. (shrink)

El presente artículo desarrolla el tema de la formación del tacto. Este tema, que desde las ciencias del espíritu llamaron bildung o formación, pone como una cuestión principal, la estética en la formación para la vida. Respecto a ello, es pertinente analizar las variables ver aquellas acciones o reflexiones que ayudan a sensibilizar y construir espacios de humanización entre los hombres. En el contexto pedagógico, se requieren, de las mismas exigencias del tacto, tanto para la educación superior en la formación (...) docente y, para estudiantes secundarios. Se trata de pensar los procesos pedagógicos desde la estética. Para desarrollar el tema hemos abordado la lectura desde dos autores base: Hans-Georg Gadamer y John Dewey, que desde una lectura hermenéutico pragmática, situamos como un elemento central de la formación estética a la conversación. De este modo, la importancia del tacto nos pone en estrecha relación con la importancia de la estética en la formación profesional docente, como en el propio ejercicio de quienes ejercen el oficio de ser maestros, pues construir el sensus communis es el desafío de un maestro de saber y conocer; que, desde el tacto, abre la oportunidad de encontrar en la conversación, una experiencia que forma y proyecta. (shrink)

Selected-effects theories provide the most popular account of biological teleology. According to these theories, the purpose of a trait is to do whatever it was selected for. The vast majority of selected-effects theories consider biological teleology to be introduced by natural selection. We want to argue, however, that natural selection is not the only relevant selective process in biology. In particular, our proposal is that biological regulation is a form of biological selection. So, those who accept selected-effects theories should recognize (...) biological regulation as a distinctive source of biological teleology. The purposes derived from biological regulation are of special interest for explaining and predicting the behavior of organisms, given that regulatory mechanisms directly modulate the behavior of the systems they regulate. This explanatory power, added to the fact that regulation is widespread in the biological world, makes the idea that regulation gives rise to its own form of teleology a substantial contribution to the debate on biological teleology. (shrink)

In this paper, we bring together the concepts of affordance from ecological psychology and function from the organizational approach to philosophy of biology into a single integrative framework. This integration allows us to account for the biological basis of the notion of affordance, offering theoretical tools to address the normative interrelations between organisms and their environments.

In this paper, we analyze the debate between the Modern Synthesis and the Extended Evolutionary Synthesis in light of the concept of incommensurability developed by Thomas Kuhn. In order to do so, first we briefly present both the Modern Synthesis and the Extended Evolutionary Synthesis. Then, we clarify the meaning and interpretations of incommensurability throughout Kuhn’s works, concluding that the version of this concept deployed in The Structure of Scientific Revolutions is the best suited to the analysis of scientific disputes. (...) After discussing incommensurability in Kuhn’s works, we address the question of whether the Modern Synthesis and the Extended Evolutionary Synthesis can be considered semantically, methodologically, and ontologically incommensurable, concluding that they can. Finally, we discuss three problems that arise from such a conclusion: firstly, what are the consequences of incommensurability; secondly, which mode of scientific change better explains this current dispute in evolutionary biology; and thirdly, whether rational theory comparison is possible given incommensurability. We suggest that the main consequence of incommensurability is profound disagreement, that the kind of scientific change that better explains the current dispute between the MS and the EES may be scientific specialization, and that incommensurability does not preclude rational theory comparison. (shrink)

La noción de emergencia acompaña a la Filosofía de la Biología desde finales del siglo XIX, afirmando que las propiedades de los sistemas biológicos no pueden deducirse de las de sus componentes. A lo largo del siglo XX las caracterizaciones de este concepto se han apoyado en cuatro pilares, impredecibilidad, novedad, restricción y causación descendente, pilares ligados a la asunción de una jerarquización de la realidad en niveles de organización. En este trabajo intento demostrar que puede explicarse la naturaleza de (...) las propiedades biológicas sin hacer referencia a la emergencia utilizando como herramienta la noción de cuasi-descomponibilidad propuesta originariamente por Herbert Simon. (shrink)

In this paper we articulate a characterization of the concept of disease as a social problem. We argue that, from a social ontology point of view, diseases are problems that are identified and addressed within the framework of concrete social institutions and practices (those that shape medicine). This approach allows us to overcome the classical distinction between naturalist and normativist approaches in the philosophy of medicine, taking into account both the material and the symbolic factors that shape the categories and (...) determine the practices of medicine. (shrink)

The notion of emergence has accompanied philosophy of science since the late XIX century, claiming that in some systems there are properties in certain levels that cannot be deduced from properties of their components as seen in more fundamental levels. Throughout the XX century, emergence has been characterized by four pillars: unpredictability, novelty, restriction and downward causation. These four pillars have been related to the assumption of a hierarchical order of reality in different levels of organization. In this paper, we (...) show that it is possible to explain the nature of the emergent properties through the nearly-decomposability criterion introduced by Herbert Simon. (shrink)

El proyecto del ‘Darwinismo Formal’ de Alan Grafen propone una formulación matemática de la teoría de Darwin que pretende demostrar que la selección natural moldea los rasgos fenotípicos a través de la maximización de la eficacia. El proyecto de Grafen reposa sobre tres premisas: la selección natural es la única fuerza que moldea los fenotipos; la eficacia es la única medida de le evolución; y el diseño biológico surge como resultado de un proceso de optimización selectiva. En este trabajo argumentamos (...) que estas tres premisas limitan la aplicabilidad del modelo a los hechos evolutivos más simples. Esto se debe a que Grafen implícitamente presupone un concepto de eficacia que es a la vez causa y efecto de las novedades fenotípicas; lo que, por un lado, vacía la teoría de Darwin de poder explicativo y, por el otro, lleva a ignorar la potencial contribución de fuerzas evolutivas no selectivas en la configuración de la complejidad biológica. Para superar estos escollos del proyecto de del Darwinismo Formal - que son además comunes a todos los modelos formales adaptacionistas - proponemos sustituir el concepto causal de eficacia por el de robustez, definiendo así el diseño biológico como forma y función en lugar de como maximización de la eficacia. (shrink)

En este trabajo analizamos críticamente el enfoque mecanicista de explicación científica centrándonos principalmente en la forma en la que este da cuenta de los fenómenos biológicos. Nos proponemos complementar esta perspectiva con una concepción de nivel como intervalo de cuasi-descomponibilidad que nos permite fundamentar metafísicamente las propuestas mecanicistas clásicas en las propiedades sistémicas características de las entidades biológicas. A través del análisis de ejemplos concretos, demostraremos cómo nuestra propuesta permite superar algunas de las limitaciones de los enfoques predominantes de explicación (...) mecanística. (shrink)

En la intersección entre la ética aplicada y los estudios sobre divulgación científica en los medios, este trabajo propone un concepto de «cultura bioética» y lo aplica a la exitosa serie de televisión House. Nuestro análisis de la serie muestra la relación existente entre la tensión entre autonomía del paciente y paternalismo médico presente en la teoría bioética y la práctica asistencial, por un lado, con el debate abierto en filosofía de la medicina entre posiciones naturalistas y normativistas sobre los (...) conceptos de salud y enfermedad, por el otro. Se propone también una ampliación del concepto de autonomía que permita avanzar en la resolución de esta tensión, tanto a nivel teórico como práctico. (shrink)

In this paper, we critically analyze the mechanicist approach to scientific explanation and propose to complement this view with a conception of level as interval of quasi-decompositionality. This conception allows us to metaphysically base the mechanicist proposals on characteristic systemic features. By means of concrete examples, we claim that this proposal is able to overcome some of the alleged limitations of predominant models of mechanistic explanation.

En este artículo me interesa abordar el carácter terapéutico de la filosofía socrática según los diálogos aporéticos de Platón. Considero que la terapia de Sócrates es un cuidado de sí mismo cuyo ejercicio se lleva a cabo con los otros de manera dialéctica, por lo cual la naturaleza de sí mismo no es nunca resultado de una reflexión aislada, sino una búsqueda constante a través del diálogo. Para ello es necesario aclarar el sentido de la relación que establece el diálogo (...) socrático, la estructura de la pregunta terapéutica y el objetivo que motiva la terapia socrática. (shrink)

Los conceptos de evolución y cambio evolutivo son a la vez laxos y polisémicos: se aplican a fenómenos muy diferentes y no siempre se definen con precisión. La aplicación extendida del paradigma neo-darwinista clásico, además, suele imponer un esquema adaptacionista al análisis de los hechos evolutivos, en el cual las funciones juegan un papel lógicamente anterior a los rasgos y sus formas. En este artículo proponemos, como etapa previa a la formulación de hipótesis sobre las causas del cambio, un modelo (...) de espacio forma-función que pueda responder a preguntas como cuándo se da un cambio en los rasgos de una arquitectura biológica y de qué tipo son estos cambios. Un modelo de este tipo nos permite ver claramente cuándo se da un cambio en la forma o en la función y qué alcance evolutivo tiene. (shrink)

Darwin’s claim that Natural Selection, through optimization of fitness, explains complex biological design has not yet been properly formalized. Alan Grafen’s Formal Darwinism Project aims at providing such a formalization and at demonstrating that fitness maximization is coherent with results from Population Genetics, usually interpreted as denying it. We suggest that Grafen’s proposal suffers from some limitations linked to its concept of design as optimized fitness. In order to overcome these limitations, we propose a classification of evolutionary facts based on (...) a bi-dimensional complexity space, which adds robustness to fitness as measure of the quality of a design. In this space, each point represents an organismic architecture, and movement between two points would be an evolutionary fact. Natural Selection explains movement along the fitness axis, while non-selective mechanisms explain movement on the robustness axis. Moreover, we propose a thermodynamic metaphor to draw parallelisms between notions of fitness and entropy, robustness and energy, and movement in this space and reversible and irreversible cycles. We argue that this metaphor illustrates different evolutionary processes usually overlooked by proposals of formalization of Darwinian theory, such Grafen’s Formal Darwinism Project. (shrink)

RESUMEN Este artículo pretende comprender la filosofía de Platón como un ejercicio esencialmente político. Esto implica, sin embargo, distinguir cómo se ejerce esta filosofía política, su sentido y alcance. Muchos estudiosos han atribuido a Platón el proyecto político que Sócrates desarrolla en la República. Sin embargo, el símil de la caverna da cuenta de la imposibilidad o, al menos, de la interna problematicidad de tal proyecto, por lo cual se sugiere que no es en el diálogo República donde se encontraría (...) la auténtica filosofía política de Platón, sino en los denominados diálogos aporéticos. En estos diálogos no se habla sobre una posible ciudad, sino que se ejercita de manera viva una política desarrollada por la dialéctica terapéutica de Sócrates, cuya tarea es desvelar la virtud mediante el desenmascaramiento de los rostros de la ciudad. ABSTRACT The following paper contends that Plato's philosophy is essentially a political activity. This imply, however, to distinguish how this political philosophy carries out, its meaning and scope. Many scholars have attributed to Plato the political project, which Socrates develops in the dialogue Republic. Nevertheless, the simile of the cave reveals the impossibility of such a project or, at least, the serious problems that lie behind it. So, I suggest, that is not in the dialogue Republic where it finds Plato's authentic political philosophy, but in the so-called aporetic dialogues. In these dialogues it does not discuss about a possible city, but it exercises in a lively way a politics builted by Socrates' dialectic therapy, whose task is unveiling the virtue through the unmasking the faces of the city. (shrink)

This study aimed to investigate the student-athletes' capability to face the academic, sport, and social challenges during the coronavirus disease 2019 (COVID-19) lockdown and to disclose novel aspects of dual careers. A 32-item online survey encompassing demographic characteristics, sport and university engagement, support and dual-career benefits, physical activity, sitting time, and the time deemed necessary to recover the previous level of performance was developed. Four hundred sixty-seven student-athletes (males: 57%, females: 43%) from 11 countries, competing in 49 different sports (individual: (...) 63.4%, team: 36.6%) at regional (17.5%), national (43.3%), and international (39.2%) levels, and enrolled at high school (21.9%) and university (78.1%) levels completed the survey. During the lockdown, the respondents decreased the time dedicated to sport and academics, although they maintained an active lifestyle. Student-athletes from countries under severe contagion were more likely to train at home, dedicate to academics, and receive support from the coach but less likely receive support from their teachers. With respect to their team sport counterparts, athletes competing in individual sports trained more and were more likely to receive support from their coaches. International athletes showed the highest training time and support from their coaches and as student-athletes. High school students received more support from their coaches and teachers, whereas university students were more likely considering dual careers useful to cope with the COVID-19 pandemic. This study substantiates the relevant role of competitive sports participation in the maintenance of active lifestyles, with student-athletes considering home training and e-learning valuable resources during the lockdown. Furthermore, their sport and academic commitments helped student-athletes cope with the emergency of the COVID-19 pandemic. (shrink)

Tenemos aquí, un libro sobre Psicología Humanista y Transpersonal. Un libro que indaga e ilumina esta orientación psicológica en Chile. Su historia, sus protagonistas, sus historias, sus planteamientos y testimonios.Se trata de un libro. Hay todo un mundo escrito y descrito. Sin embargo, no es un libro para leer. Y esa es la paradoja de todo lo que está escrito en él. Es un libro para escuchar, para contemplar. Una larga y profunda conversación. Una experiencia acerca de las experiencias de (...) s.. (shrink)

Este libro reciente de Cristian Saborido sobre filosofía de la medicina, que, como no abunda, se titula fundacionalmente en forma homónima, _Filosofía de la medicina, _es un texto dedicado tanto a filósofos de la ciencia, como a profesionales de la salud. En tal sentido es un libro para el estudio de una disciplina de la filosofía y, a la vez, un texto para indagar y provocar la reflexión de quienes llevan a cabo la práctica de las ciencias médicas. (...) Aquí nos ocuparemos de analizar las principales inquietudes que presenta Saborido para desglosarlas y comprender su alcance. (shrink)

Charles E. SCOTT, Susan M. SCHOENBOHM, Daniela VALLEGA-NEU, Alejandro VALLEGA, Companion to Heidegger’s Contributions to Philosophy, IndianaUniversity Press, Bloomington & Indianapolis, 2001 ; Gernot BÖHME, Aisthetik. Vorlesungen über Ästhetik als allgemeine Wahrnehmungslehre, Wilhelm Fink Verlag, München, 2001 ; Dean KOMEL, Osnutja k Filozofski in Kulturni Hermenevtiki [Outlines to Philosophical and Cultural Hermeneutics], Nova revija, Ljubljana, 2001 ; Marc RICHIR, L’institution de l’idéalité. Des schématismes phénoménologiques, Association pour la promotion de la Phénoménologie, Paris, 2002 ; Fred EVANS & Leonard LAWLOR, (...) Chiasms. Merleau-Ponty's Notion of Flesh, State University of New York Press, 2000 ; Udo TIETZ, Ontologie und Dialektik. Heidegger und Adorno über das Sein, das Nichtidentische, die Synthesis und die Kopula, Passagen Verlag, Wien, 2003 ; Etienne FERON, Phénoménologie de la mort. Sur les traces de Levinas, Kluwer Academic Publishers, Dordrecht, Boston, London, 1999. (shrink)

El presente artículo busca proponer un acercamiento a la influencia del pensamiento de Thomas Hobbes y su obra en el pensamiento económico. En especial en las escuelas marxista, neoclásica y keynesiana. El influjo de su pensamiento puede evidenciarse en el abordaje metodológico, antropológico e institucional. Se ofrece una Mirada sobre la sociedad civil (comercial), el Mercado y el Estado al mismo tiempo. Hobbes ha sido la inspiración de un concepto de Estado monolítico en lo político, en este sentido, la mirada (...) de la economía bajo el concepto de un gran planificador centralizado, tiene importantes antecedentes en este autor. El ejercicio del control social del individuo como propuesta institucional, en varias escuelas de la economía comparten con Hobbes, varios antecedentes que merecen ser analizados. (shrink)

We examined the relationship among watching soccer matches, moral functioning and aggression levels in 332 college students. Hypothesis-driven regression analyses revealed that the frequency of watching soccer matches was positively associated with low levels of moral behavior and high aggression levels. A mediation analysis also showed that moral behavior mediated the relationship between the frequency of watching soccer matches and aggression levels. Males manifested lower levels of moral functioning and higher hostility, physical and verbal aggression than females when watching a (...) soccer match. Moreover, only males reported more verbal aggression and anger when watching soccer matches as compared to their general aggression levels. (shrink)

It has been reported in non-contingent schedules that the variety of patterns of behavior is affected by the temporal variation of water deliveries. While temporal variation is accomplished by delivering water at fixed or variable times, spatial variation is usually accomplished by varying the number of dispensers and distance among them. Such criteria do not consider the possible ecological relevance of the location of water dispensers. Nevertheless, it is plausible to suppose that the intersection of the programed contingencies, the ecological (...) differentiated space, and the relative location of relevant objects and events could set up an integrated system with the behavioral patterns of the organism. In the present study, we evaluated the eco-functional relevance of two locations of the dispensers upon behavioral dynamics in Wistar rats using fixed and variable time schedules in a modified open-field system. In Experiment 1, three subjects were exposed to a fixed time 30-s water delivery schedule. In the first condition, the water dispenser was located at the center of the experimental chamber. In the second condition, the water dispenser was located at the center of a wall of the experimental chamber. Each location was present for 20 sessions. In Experiment 2, conditions were the same, but a variable time schedule was used. Routes, distance to the dispenser, recurrence patterns, time spent in zones, entropy, and divergence were analyzed. Our findings suggest a robust differential relevance of the location of the dispensers that should be considered in studies evaluating behavioral dynamics. Results are discussed from an integrative, ecological-parametric framework. (shrink)